Real Madrid suffered a shock 2-0 loss and finished with nine men against Celta Vigo in LaLiga on Sunday.
Spain face Ronald Koeman's Netherlands away on Thursday before returning home for the second-leg on March 23.
A late penalty from Bryan Zaragoza secured Spain a 3-2 win over Switzerland in their final Nations League Group A4 game on Monday.
Croatian forward Ante Budimir scored twice to help Osasuna earn a shock 4-2 home win over leaders Barcelona.
Bayer Leverkusen crushed hosts VfL Bochum 5-0 to stretch their remarkable unbeaten run across all competitions this season to 50 consecutive matches.
